Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces

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چکیده

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Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces.

While it is well known that individual integrins are critical mediators of cell behavior, recent work has shown that when multiple types of integrins simultaneously engage the ECM, cell functions are enhanced. However, it is not known how integrins spatially coordinate to regulate cell adhesion because no reliable method exists to segregate integrins on the cell membrane. Here, we use a microco...

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ژورنال

عنوان ژورنال: Integrative Biology

سال: 2011

ISSN: 1757-9694,1757-9708

DOI: 10.1039/c0ib00129e